antenatal screening programme
Sickle cell and Thalassaemia
Sickle Cell disorders are a group of genetic conditions. In these disorders some red blood cells are sickle shaped which causes them to clump together. These clumps can then get stuck in the small blood vessels. This can then cause an inflammatory reaction.
ß Thalassaemia is also a inherited condition which causes progressive anaemia. It is common in the Mediterranean, Asian, South East Asian and Middle Eastern countries. It can be life threatening.
Read more about sickle cell and thalassaemia on the NHS website.
UK NSC screening recommendation
From April 2005, enhanced laboratory screening should be offered to all women in units defined as high prevalence. High prevalence is defined as a fetal prevalence of sickle cell disorder greater than 1.5 per 10,000 pregnancies.
Supporting documents from the 2006 review
Screening around the UK
The UK NSC recommends screening for this condition, however this may vary slightly depending on where you are in the UK.
Date previous review completed: 2006
Next review estimated to be completed: 2021 to 2022.
To see previous evidence reviews, visit the UK NSC archive.
Organisations interested in Sickle cell and Thalassaemia
These organisations have expressed interest in this recommendation and may submit responses to evidence reviews.
List of organisations
- All Party Parliamentary Group for Sickle Cell and Thalassaemia
- Faculty of Public Health
- Genetic Alliance UK
- Oscar Birmingham
- Oscar Bristol
- Oscar Trust
- Royal College of General Practitioners
- Royal College of Midwives
- Royal College of Obstetricians and Gynaecologists
- Royal College of Physicians
- Royal College of Physicians and Surgeons of Glasgow
- Royal College of Physicians of Edinburgh
- Sickle Cell Anaemia Relief Foundation
- Sickle Cell Anaemia Research
- Sickle Cell Care Centre
- Sickle Cell Society
- Sickle Cell & Thalassaemia Association of Counsellors
- Sickle Cell Women's Welfare Association
- Sickle Watch
- UK Thalassaemia Society